To meet this need, Blanchard Lab engineers multicellular, stem cell–derived 3D human brain tissues that model key aspects of neurodegeneration in a physiologically relevant human context. They use these platforms to dissect disease mechanisms, identify therapeutic vulnerabilities, and accelerate translational discovery.
Creative Biolabs is honored to invite Dr. Joel W. Blanchard to present a webinar titled “Decoding the Mechanisms Underlying Susceptibility to Neurodegeneration with iPSC-Derived Human Brain Tissue“.
In this talk, Dr. Joel W. Blanchard will highlight three examples of this approach:
- How a rare genetic mutation drives severe juvenile PD, revealing a lysosome–polyamine–epigenetic axis of neurodegeneration.
- How APOE4 promotes α-synuclein co-pathology through glial dysfunction.
- How APOE4 drives cerebrovascular remodeling and blood–brain barrier dysfunction in AD.
Together, these studies illustrate how engineered human brain models can uncover disease mechanisms inaccessible in traditional systems and open new paths toward therapeutics.
- https://neuros.creative-biolabs.com/decoding-the-mechanisms-underlying-susceptibility.htm
- 2026-07-14
- 10:00
- 2026-07-14
- 11:00
- https://neuros.creative-biolabs.com/decoding-the-mechanisms-underlying-susceptibility.htm
- Creative Biolabs
- 6318306441